They indicated the value of these markers for monitoring patients with urticaria, especially those with positive ASST, and suggested the prognostic role of various biomarkers related to angiogenesis, coagulation and vascular dysregulation, including vascular endothelial growth factor (VEGF), endostatin (ES), thrombospondin-1 (TSP-1), matrix metalloproteinase-9 (MMP-9), soluble VE-cadherin (sVE-cadherin) and the soluble forms of ICAM-1 and VCAM-1, the latter in agreement with our current findings [13]. The gene discussed is MMP9; the disease is urticaria.