ESR1 and cancer: Bicluster 1 CpGs were found enriched in binding regions of TFs including GRHL2, TFAP2C, FOXA1, ER, CEBPB and NR5A2, TFs known to be important in many cancer‐related functions such as proliferation, stemness and epithelial‐to‐mesenchymal transition (EMT) (Fig. 3D upper panel).