Further, several of the genes with increased expression in intra- compared to extracranial metastases predicted in at least 11 of 16 melanoma patients could potentially be of therapeutic relevance for the development of targeted treatment strategies for intracranial metastases (e.g. PPBP, HEPACAM, SLC24A2, SLC38A11, FMN2, PMP2). Here, FMN2 is linked to melanoma.