Unlike the many other AD-DD genes, the phenotypes linked with GATA6 haploinsufficiency are both specific and severe enough that we considered it implausible they would not be recorded in the linked electronic health records of UKB participants; importantly, we note that none of the 30 carriers have any indication of either pancreatic agenesis or cardiac malformations. This evidence concerns the gene GATA6 and pancreatic agenesis.