Canonical pathways upregulated in order of most to least significance were (overlap percentage): S100 family (5.2%), G-protein coupled receptor (GPCR) signaling (5.1%), pulmonary fibrosis idiopathic signaling pathway (6.4%), molecular mechanisms of cancer (4.6%), cAMP response element binding protein (CREB) signaling in neurons (4.9%). Here, CREB1 is linked to pulmonary fibrosis.