We detected a significantly decreased level of mBDNF, TrkB and CPE but a relatively higher level of proBDNF in the DG of 9-MO APP/PS1 mice compared to the age-matched WT mice (Fig. 4b and Additional file 1: Fig. S3b), suggesting the presence of an imbalance between pro-BDNF and mBDNF in AD mice. This evidence concerns the gene APP and Alzheimer disease.