LRP5 and autosomal dominant polycystic liver disease: A recent study has shown that heterozygous mutations of the low-density lipoprotein receptor-related protein 5 (LRP5) gene, particularly p.R1188W variant, can lead to ADPLD; however, another study reported that some variants of LRP5, such as rs724159825, can also lead to ADPKD [65, 66].