A study with 129 participants with ADPKD revealed that mutation position and mutation type (truncating mutation: nonsense, frameshift, and splicing mutation; or non-truncating mutation: substitution) can affect the severity of hepatic cystogenesis, and patients with PKD1 nonsense mutations exhibit more severe hepatic cystogenesis [16]. Here, PKD1 is linked to autosomal dominant polycystic kidney disease.