ARL3 and autosomal dominant polycystic liver disease: Using tissues from patients with ADPLD and in vivo and in vitro experiments, it was shown that increased HDAC6-mediated ubiquitination and deregulated autophagy of ciliogenic proteins such as ADP-ribosylation factor-like protein 3 (ARL3) and ADP-ribosylation factor-like protein 13B (ARL13B) in cholangiocytes promote hepatic cystogenesis [87, 88].