A main strength is the use of gold standard methods to assess myocardial glucose metabolism by cardiac 18F-FDG PET scan combined with euglycemic hyperinsulinemic clamp technique, which allows the valuation of insulin-stimulated myocardial glucose uptake under uniform experimental conditions of euglycemia and physiological hyperinsulinemia [17, 42]. This evidence concerns the gene INS and hyperinsulinism.