To elucidate the mechanism underlying SF3B3-mediated regulation of CRC cell growth, we treated SF3B3-knockdown cells with ZVF (Z-VAD-FMK, a pan-caspase inhibitor of apoptosis), NSA (necrosulfonamide, an inhibitor of necroptosis), or ferroptosis inhibitors (Lip-1, liproxstatin-1; Fer-1, ferrostatin-1). Here, SF3B3 is linked to colorectal carcinoma.