To investigate the in vivo function of SF3B3, we utilized a lentivirus-mediated shRNA system to construct stably SF3B3-knockdown CRC cells (LoVo-shSF3B3#1, LoVo-shSF3B3#2 cells, HT29-shSF3B3#2 cells) for mouse CRC models (Fig. S3A-B). This evidence concerns the gene SF3B3 and colorectal carcinoma.