VEGFA and rheumatoid arthritis: Recent findings suggest that PTEN deficiency can amplify the survival and growth of FLS in RA, potentially due to PTEN’s regulatory role in the secretion and release of inflammatory factors associated with RA-FLS, including interleukin (IL)-6/1β, chemokine (C-C motif) ligand (CCL)-23, and vascular endothelial growth factor (VEGF) [18, 19].