We also observed a suggestive association between genetically determined higher circulating IP-10 and a 55.3% increased risk of MPN (OR:1.553, 95% CI:1.088–2.216, P = 0.015), and it did not show heterogeneity (Cochrane Q test, P = 0.706)(Fig. 2A); nor did it show directional pleiotropy (MR egger-intercept = 0.085, P for MR egger-intercept = 0.305, P for MR PRESSO global test = 0.668) (Supplementary Table 5). Here, CXCL10 is linked to myeloproliferative disorder.