In analyzing the effect of MPN on inflammatory factors, We found a suggestive association between genetically predicted MPN and levels of the cytokines IL-10, MIG, and RANTES. Genetically predicted MPN were suggestively associated with levels of interleukin-10 (IL-10) (BETA = 0.033,95% CI = 0.003 ~ 0.064, P = 0.032) and Monokine induced by interferon-gamma (MIG) (BETA = 0.052,95% CI = 0.002–0.102, P = 0.043) and Regulated on activation, normal T Cell expressed and secreted (RANTES) (BETA = 0.055,95% CI = 0.009 − 0.1, P = 0.018) using IVW methods. This evidence concerns the gene CXCL9 and myeloproliferative disorder.