Katerina et al. found that serum levels of IL-2rα were significantly elevated in patients with MPN compared to normal individuals [14], which was confirmed by further studies, where IL2rα levels were correlated with overall survival in patients with MF in MPN [41], and levels of IL-2ra in patients with MPN were positively correlated with disease progression and bone marrow angiogenesis [42]. This evidence concerns the gene IL2RA and myeloproliferative neoplasm.