This finding is not only consistent with the results of observational studies but also compensates for the shortcomings of small sample sizes and potential confounders in the observational studies mentioned above and provides more reliable evidence for the association between IL2rα and MPN at the level of genetics, emphasizing the importance and necessity of further investigating the role ofIL2rα in the development of MPN disease. This evidence concerns the gene IL2RA and myeloproliferative neoplasm.