It is interesting to note that IL-10 appears to be a protective factor against atherosclerosis, a common clinical symptom of MPN, and that, as an anti-inflammatory cytokine, IL-10 can attenuate atherosclerotic lesions by preventing dilation of inflamed areas, decreasing the size of plaques, and other mechanisms [56]. This evidence concerns the gene IL10 and myeloproliferative neoplasm.