The highest diagnostic efficacy for MF was based on the expression of IP-10 and IL-2ra (IP10: AUC = 0.958, IL-2ra: AUC = 0.938); the areas under the ROC curves of IP-10 and IL-2ra in ET, PV, and MF were greater than 0.7, suggesting that IP-10 and IL-2ra may be used as potential diagnostic markers of MPN. The gene discussed is CXCL10; the disease is acquired polycythemia vera.