DSG2 and breast cancer: To further evaluate the biological roles of reduced Dsg2 and Dsc2 in BC with different subtypes, we generated stable knockdown MDA-MB-231 and MCF-7 cell lines expressing Dsg2- specific (shDsg2), Dsc2- specific (shDsc2) and non-targeting short hairpin RNA (shRNA) controls (shControl1 and shControl2) in parallel via lentivirus transduction, respectively.