BRCA1 and cancer: Of the 556 BRCA PV carriers identified in the 11,482 cancer patients, 331(59.5%) were the carriers for the three founder variants, including 24 (4.3%) carriers of BRCA1 c.2037delinsCC, 58 (10.4%) carriers of BRCA1 c.3331_3334del, and 249 (44.8%) carriers of BRCA2 c.156_157insAlu (Fig. 2B).