Then, the GSEA analysis demonstrated that P53 signaling pathway, cytokine-cytokine receptor interaction, and intestinal immune network for IGA production were mainly enriched in the high-risk group (Fig. 7A), whereas the low-risk group exhibited significant enrichment of renal cell carcinoma, mTOR signaling pathway, and fatty acid metabolism (Additional file 1: Fig. S3F). Here, MTOR is linked to hereditary clear cell renal cell carcinoma.