As shown in Fig. 6B upper panel, comparing with PBS treatment, poly(I:C) stimulation significantly increased the inhibition rate of Hepa1-6 cell proliferation by CD8+ T cells with wild-type TLR3 gene (CD8+TLR3wt T cells) derived from HCC subcutaneous C57BL/6 mouse model (P = 0.012). Here, CD8A is linked to hepatocellular carcinoma.