Mechanistically, tumor cells damaged by local RT could release tumor-associated antigens and increase the expression level of major histocompatibility complex (MHC) class I molecules, which will benefit the uptake and presentation ability of tumor-associated antigens by dendritic cells (DCs), and then induce the infiltration and activation of CD8+ T cells to attack tumor cells (Ashrafizadeh et al, 2020; Goto, 2019). The gene discussed is CD8A; the disease is neoplasm.