TLR3 and neoplasm: In summary, all the above results elucidated that poly(I:C) could improve RT-induced ferroptosis in RT targeted tumor and distant tumor by promoting the tumor antigen presentation ability of DC and stimulating the TLR3 activated CD8+ T cell infiltration in tumor tissues to secrete ferroptosis-related factors, thus increasing the frequency and potency of abscopal effect of RT in HCC (Fig. 6G).