Further detection of the culture supernatant of CD8+TLR3wt T cells by mass spectrometry found that poly(I:C)-stimulated CD8+TLR3wt T cells could specifically secrete some ferroptosis associated proteins (such as GOT1, and CTSB) to induce tumor ferroptosis when compared with PBS simulated CD8+TLR3wt T cells (Dataset EV2). This evidence concerns the gene CTSB and neoplasm.