With these assays, we first found that Atm loss significantly impeded the progression of murine AML induced by LSCs containing MLL-AF9, determined by the analysis of YFP+ cells in the peripheral blood (Fig. 1A, B) and Kaplan-Meier survival curves of transplanted recipient mice (Fig. 1C, D). The gene discussed is KMT2A; the disease is acute myeloid leukemia.