While studies have shown that phosphorylation at S1382/S1386 by I-Kappa-B kinase alpha (IKKA) increases the acetyltransferase and transcriptional activities of CBP to promote tumour cell growth [45], no study has reported the stability-associated posttranslational protein modification of CBP, except for ubiquitination. The gene discussed is CREBBP; the disease is neoplasm.