According to recent studies, the stability of the DOT1L protein is conferred by several posttranslational modifications, such as O-GlcNAcylation and acetylation, which prevent DOT1L from binding to E3 ubiquitin ligases and subsequent proteasome degradation, respectively, in MLLr leukaemia cells and colorectal cancer cells [23, 24]. Here, DOT1L is linked to colorectal cancer.