CPLX1 and essential thrombocythemia: We identified an intronic variant in CPLX1 that confers risk of ET (rs13128363-T, P = 9.0 × 10−15, OR = 1.14, Fig. 3 and Supplementary Data 3) and is the top cis-eQTL for the gene in whole blood (Supplementary Data 7).