For instance, GR has been shown to interact with FOXA2 in hepatocytes to promote gluconeogenesis13, with FOXA1 in prostate cancer cells to stimulate androgen receptor (AR)-regulated pathways under androgen-deprived conditions14, with MYOD1 in muscle fibers to negatively regulate muscle mass15, and with forkhead box O1 (FOXO1) to induce muscle atrophy in C2C12 cells exposed to DEX16. The gene discussed is FOXO1; the disease is prostate cancer.