AR and Familial prostate cancer: For instance, GR has been shown to interact with FOXA2 in hepatocytes to promote gluconeogenesis13, with FOXA1 in prostate cancer cells to stimulate androgen receptor (AR)-regulated pathways under androgen-deprived conditions14, with MYOD1 in muscle fibers to negatively regulate muscle mass15, and with forkhead box O1 (FOXO1) to induce muscle atrophy in C2C12 cells exposed to DEX16.