According to earlier studies, the SETD7 gene promotes the occurrence and propagation of cancers and may play different roles in tumour development, for example promoting the metastasis of triple-negative breast cancer by Yin Yang 1 lysine methylation [34] and promoting bladder cancer progression and immune escape via the STAT3/PD-L1 cascade [35]. Here, CD274 is linked to urinary bladder carcinoma.