In our study, we found that the expression levels of YAP1 protein were significantly decreased after SETD7 knockdown in GC cells, which was reversed by rescue experiments, while SETD7 mutants (SETD7H297A) did not decrease the expression levels of YAP1 protein, indicating that SETD7 inhibits ubiquitination and degradation of YAP1 depending on its methyltransferase activity. This evidence concerns the gene YAP1 and gastric cancer.