ACAT1 and Familial prostate cancer: Acetyl-CoA acetyltransferase (ACAT) consists of a family of two universal metabolic enzymes located in the cytoplasm (ACAT2) and mitochondria (ACAT1) [11, 12]; among these enzymes, ACAT1 has been shown to promote the tumour growth and metastasis of MDA-MB-231 breast cancer cells [13] and is highly expressed in prostate cancer tissue [14].