VSV-induced Ifn-β and Cxcl10 expression in spleen and liver showed no difference between WT and Irf3_P10A mice after treatment with FG4592 (Supplementary Fig. 15h, i), suggesting that EGLN1 indeed mediates the difference between WT and Irf3_P10A mice in response to viral infection. The gene discussed is EGLN1; the disease is viral infectious disease.