Nonetheless, we cannot exclude that the establishment of an immunosuppressive microenvironmental contexture in SEMA3Ahigh tumours is also contributed by stromal-derived SEMA3A as well as by SEMA3A-induced neural plasticity.66 Furthermore, we found that SEMA3Ahigh tumours were more resistant to gemcitabine treatment than the SEMA3Alow tumours, which perfectly aligns with the more aggressive biological behaviour of SEMA3Ahigh tumours. This evidence concerns the gene SEMA3A and neoplasm.