SEMA3C and neoplasm: Overall, the expression level of both Sema3a and Sema3c was variable among stage-matched organoid cultures (ie, PanIN, tumour and metastases) from the KC (KrasLSL-G12D/+;Pdx-1-Cre) and KPC (KrasLSL-G12D/+;Trp53LSL-R172H/+;Pdx-1-Cre) mouse models26 27 (online supplemental figure S1D).