SEMA3A and cancer: Most of the previous studies in PDAC have focused on investigating the role of members of the Slit/Robo axis on the PDAC malignant traits of PDAC as well as its cell identity.17 19–22 Of the four classes of ligands, semaphorins represent the largest family and were originally identified as chemorepellent proteins in the nervous system.23 24 SEMA3A belongs to the class 3 of secreted semaphorins and its potential role in cancer still needs to be elucidated.