Cytometric analyses of blood samples from tumour-bearing mice also confirmed the reduction of F4/80+cells with no significant effect on Ly6C+Ly6G+ or Ly6C+ cells (online supplemental figure S7F), which is in line with the inhibition of CSF1R in mouse PDAC using a small molecule.10 Only in tumours established by SEMA3A overexpressing cells, the depletion of macrophages was associated with increased intratumoural infiltration by CD8+T cells (figure 7E). The gene discussed is SEMA3A; the disease is neoplasm.