GPR26 and major depressive disorder: All three workflows reported Gpr26 to be significantly downregulated in PFC (>1.6-fold, adjusted p < 0.05) and moderately downregulated in HIP (>1.3-fold, adjusted p < 0.05) of depression mice, in line with the finding that Gpr26 KO mice displayed increased levels of anxiety- and depression-like behaviors (41).