DNER and acute myeloid leukemia: ,37 Here, acute myeloid leukemia (AML) cells were cultured in the presence of gradually escalating doses or an upfront high dose of cytarabine (AraC), a conventional chemotherapy used routinely in the clinic, or IBET-151 (IBET), a targeted epigenetic therapy against the BET (bromodomain and extra-terminal domain-containing) family of transcriptional co-activators that has shown pre-clinical efficacy against several AML subtypes37 (Figure 2A).