Other BKI analogs based on a 5- aminopyrazole- 4- carboxamide (AC) scaffold like BKI-1770 and BKI-1708 were tested and shown to be efficacious in the C. parvum infected IFN-γ KO mouse model, emerging as potential pre-clinical leads for cryptosporidiosis treatment (Huang et al.,2019). This evidence concerns the gene IFNG and cryptosporidiosis.