K14-high cells contribute to lung cancer metastasis potentially through inhibition of anoikis via upregulation of Gkn1.[30] The upregulation of NADPH oxidase 4 (NOX4) may promote anoikis resistance via ROS generation and the activation of EGFR.[31,32] Wang et al[33] demonstrated that the expression of SATB1 and anoikis resistance could suppress the growth and metastasis of human hepatocellular carcinoma, which was induced by hepatitis B virus (HBV)-encoded viral protein HBx. This evidence concerns the gene NOX4 and hepatocellular carcinoma.