Aniokis is a special type of PCD, caused by the incorrect attachment to the ECM or lack of ECM.[25] The pathway was proven to be critical for inhibiting the formation of tumors by neoplastic cells as a powerful protection mechanism of the body.[11] However, the resistance of tumor cells to anoikis through TrkB may lead to tumor metastasis in long-range organs.[26] Owing to its key role in tumor metastasis, anoikis is regarded as a significant step in cancer regulation. Here, NTRK2 is linked to neoplasm.