Previous studies found that hyperplasia of the prostate epithelium and stroma in BPH patients was associated with all 3 of these MAPK cascades.[30–32] As a transcription factor downstream of AKT, the Fox O signaling pathway similarly promotes apoptosis while inhibiting the cell cycle progression and autophagy.[33] A previous study found that downregulation of the FoxO signaling pathway may be related to the pathogenesis of BPH.[34]. The gene discussed is AKT1; the disease is benign prostatic hyperplasia.