Skin biopsy of xanthelasmas was performed in May 2021, documenting infiltration of foamy histiocytes, expressing CD68 (+), Cd1a (−), BRAFV600E (−) at the immunohistochemical analysis.[7] Genetic evaluation through Polymerase Chain Reaction (PCR) amplification was performed despite the negative results of immunohistochemical analysis, and the BRAFV600E mutation was identified. The gene discussed is CD1A; the disease is Xanthelasma.