GPX4 and myocardial infarction: For every increase of 100 μg/L in serum ferritin, the risk of AMI increases by 0.2 times.[7] In MI models, a decrease in the level of ferritin heavy chain 1 (FTH1) at the infarct site leads to elevated levels of free iron and oxidative stress, which promotes iron-mediated cell death, resulting in myocardial cell death and the occurrence of MI.[18] In addition, GPX4 protein levels are reduced in MI tissues compared to normal tissues, leading to iron death and ultimately to the development of AMI.[19]