CPLANE1 and ciliopathy: Moreover, silencing of the JS-related protein C5orf42 was found to create defects in axonal development at the dorsal root ganglion of sciatic nerves, providing further evidence that the primary cilium participates in PNS development.[6] Likewise, an association between ciliopathy and PNS dysfunction has been suggested, but a relationship between JS and PNS dysfunction has not been reported in clinical settings.