HDACs inhibit NF-κB nuclear translocation, preventing their entry into the nucleus and activation of the NF-κB pathway, consequently, imparts a certain degree of anti-inflammatory action.[69] However, the specific mechanistic impact of HDACs on PD remains unclear, and whether it directly leads to the death of dopamine neurons or follows alternative pathways necessitates further in-depth investigation. The gene discussed is NFKB1; the disease is Parkinson disease.