LRRK2 and Parkinson disease: Due to the mechanism of gene transcription inhibition by HDACs, certain HDACs, particularly those of Class I, can induce reduced expression of the a α-Syn encoding gene (SNCA gene).[66] This phenomenon, in turn, affects the production of α-Syn, leading to decrease aberrant aggregation of α-Syn and an reduced risk of PD.[67] Additional research indicates that HDACs influence the stability of leucine-rich repeat kinase 2 (LRRK2) protein, which is rich in leucine residues, through various pathways, including transcription and post-translational modifications.