Previous studies have shown that albumin was a biomarker for systemic inflammation, and hypoalbuminemia indicated that patients were in a state of systemic inflammation.[34] Systemic inflammation is not only the main cause of malnutrition but also an important factor leading to tumor progression.[35–38] In the inflammatory state, the synthesis of albumin is suppressed by some cytokines.[39] At the same time, albumin degeneration occurred to oxidative stress.[40] Hypoalbuminemia can also lead to decreased immune function thus leading to tumor progression. This evidence concerns the gene ALB and Hypoalbuminemia.