HSPB6 and diabetes mellitus: For example, diabetic cardiomyocytes secrete exosomes with lower levels of Hsp20, and the restoration of Hsp20 in these exosomes attenuates cardiac dysfunction, hypertrophy, and fibrosis.[149,150] This suggests that Hsp20 levels in circulating exosomes could serve as a biomarker for diabetes-induced cardiac hypertrophy.