PDLIM5 and cardiac hypertrophy: Similarly, miR-27a, another fibroblast-derived miRNA, has been implicated in the progression of cardiac hypertrophy through its targeting of PDZ and LIM domain 5 (PDLIM5).[156–158] Additionally, fibroblast exosomal-derived miR-21_3p (miR-21*) has been identified as a potent paracrine-acting RNA molecule inducing cardiomyocyte hypertrophy by silencing SORBS2 and PDLIM5.[159]