STAT3 and cardiac hypertrophy: Similarly, Hsp90 and IL-6 in cardiomyocyte-secreted exosomes have been implicated in the activation of STAT-3 signaling during cardiac hypertrophy, indicating their potential as biomarkers for this pathological process.[151,152] Furthermore, the presence of AT1R-enriched exosomes released from cardiomyocytes under conditions of transverse aortic constriction suggests that AT1R levels in circulating exosomes could be a biomarker for pressure overload-induced cardiac hypertrophy.[153]