Meanwhile, Ruminococcusgnavus played a crucial role in the development of Crohn’s diseas.[36] The study in[37] suggested that Bacteroidetes reduction can lead to inflammatory cytokines (IL-6), which may damage DNA and cause chronic inflammation and inflammation-associated cancers.[38] In another research,[39] authors obtained findings that genus ErysipelotrichaceaeUCG004 and the lower profusion of Erysipelotrichaceae were evaluated correlated with H. pylori infection and can cause chronic gastritis and gastric ulcer, which supported our MR results. Here, IL6 is linked to cancer.