Key neuropathological features of AD include neurofibrillary tangles (NFTs), primarily composed of abnormally phosphorylated tau protein, extracellular deposition of amyloid-ß peptides (Aß) in senile plaques, and dystrophic neurites (Hyman et al. 2012; Montine et al. 2012). Here, MAPT is linked to Alzheimer disease.