PNPLA3 and obesity due to melanocortin 4 receptor deficiency: The association of MLXIPL Gln241His with SLD was more pronounced in subgroups with common SLD comorbidities and risk factors like T2D or obesity, as well as carriers of patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M (Figure 3).