FAH and Hypoglycemia: The glucose levels in Cas9 RNP–treated mice were significantly higher than the diseased NTBC-off controls (mean: 179.4 and 5.5 mg/dL; p = 0.0006), indicating correction in the hypoglycemia phenotype (Supplemental Figure S12, http://links.lww.com/HC9/A847) characteristic of Fah−/− mice off NTBC.52 In addition, transplantation of Cas9 RNP–treated hepatocytes resulted in the normalization of biochemical markers of renal injury and cholesterol levels compared with NTBC-off diseased controls (Supplemental Figure S12, http://links.lww.com/HC9/A847).