H&E-stained images revealed no major pathology in mice transplanted with Hpd-Cas9 mRNA or RNP (Figure 3C; Supplemental Table S2, http://links.lww.com/HC9/A847) and were consistent with the gross liver images that showed improved physiology and tumor pathology compared to controls at 100 days after transplantation (Supplemental Figure S9, http://links.lww.com/HC9/A847). This evidence concerns the gene HPD and neoplasm.