In conclusion, the present study (based on bioinformatics analysis) identified differentially expressed hub lncRNAs (AC008708.1, AC091806.1, AL442071.1, FAM111A-DT, and LINC01989) and mRNAs (BCL6, EFNB1, EPHB2, FOXO1, FOXO3, GNAI1, IRF4, PIK3R1, and RXRA) from fibroblasts bearing IPF, and BCL6 may be directly regulated by AC091806.1 and FAM111A-DT, EPHB1 by FAM111A-DT and LINC01989, and EPHB2 by AC008708.1. This evidence concerns the gene EFNB1 and idiopathic pulmonary fibrosis.