CASP3 and rheumatoid arthritis: Our findings showed that miR-4693-5p upregulated the expression of proapoptotic proteins (Bax, CytC, and caspase 3/7) and downregulated the expression of antiapoptotic protein (Bcl2) (Figure 4) via HIF1α knockdown to promote apoptotic stimulation in SW982 and RAFLS cells, indicating that miR-4693-5p inhibits apoptosis resistance in RA to control disease progression [30].