HAMP and hemochromatosis type 1: The relative importance of these stages, which are controlled by pathophysiological signals has been long debated, but recent findings, including the characterization of the hepcidin/ferroportin axis, seem to indicate that the basolateral transfer is more critical, as first suggested by studies showing that high release of iron from the intestine into the bloodstream underlies the inappropriate iron absorption found in hemochromatosis patients [47].