ATM and cancer: Jaceosidin, a bioactive flavone, is a potentially active metabolite that possesses a variety of pharmacological effects, including antioxidant, anti-inflammatory, anti-bacterial, anti-cancer, and antiallergic activities [52,53] The bioactivities and therapeutic effects of jaceosidin also include the modulation of different cell signaling pathways (ERK1/2, NF-κB, PI3K/Akt, and ATM-Chk1/2) that have been disturbed in various pathological diseases.