The 1,25-dihydroxy vitamin D/vitamin D receptor (VDR) axis can influence MAFLD progression by modulating a variety of pathways such as hepatic insulin resistance, oxidative stress, inflammation, and fibrosis, as well as regulating various hepatic cells such as hepatocytes, HSCs, and macrophages (Figure 1) [195,196]. This evidence concerns the gene VDR and Insulin resistance.