In the current study, we found that treatment with M-T807R1/Clodrosome aimed at simultaneously depleting monocytes, NK cells, and CD8+ cells prior to infection ultimately did not shorten the time to seroconversion or the induction of p24Gag antibody titers of HTLV-1WT, but it did accelerate seroconversion in macaques exposed to HTLV-1p12KO when compared with treatment with M-T807R1 alone and resulted in more consistent detection of viral DNA in the two virus groups (Figure 4; [52]). Here, CD8A is linked to infection.