IL15 and viral infectious disease: Typical host responses to virus infection follow a pattern of early induction of type 1 interferon from dendritic cells, increased IL-15 release, and NK cell and B-cell engagement, resulting in the release of cytokines/chemokines that drive a strong Th1-type adaptive response, followed by the proliferation of T lymphocytes and the production of antibodies impacting viral replication, clearance, or persistence [62].