Additionally, through in vitro bioactivity assays, it was found that compounds 177 and 174 exhibited significant inhibitory activity against the target molecule associated with type II diabetes, human protein tyrosine phosphatase 1B (PTP1B), with IC50 values of 14.9 and 17.6 μM, respectively [72,80,159]. The gene discussed is PTPN1; the disease is type 2 diabetes mellitus.