In conclusion, our findings, in conjunction with previous studies on α7 nAChR ligands like sinomenine, QND7, and APS8, emphasize the potential therapeutic efficacy of APS7-2 and APS8-2 in counteracting the pro-cancer effects of nicotine, such as increased cancer cell viability and proliferation, offering a promising pathway in lung cancer treatment. Here, CHRNA7 is linked to cancer.