Triostatin (6), echinomycin (7), and a series of synthetic derivatives were evaluated for effects on the HIF-1 transcriptional activation under hypoxic conditions and cytotoxicity on MCF-7 cells, SAR analysis indicating that the cyclic depsipeptide architecture is as an attractive scaffold to develop selective anticancer agents targeting the hypoxic tumor microenvironment [80]. Here, HIF1A is linked to neoplasm.