SIRT1 and cancer: Later, in 2015, Kim and coworkers reported psammaplin A (28) ability to induce autophagic cell death, markedly increasing the expression of damage-regulated autophagy modulator (DRAM), as well as causing the reduced expression of SIRT1, suggesting an association between SIRT1 expression and p53 acetylation in chemorresistant cancer cells [155].