HIF1A and neoplasm: 7-Phloroeckol (54) is acknowledged to inhibit tumor angiogenesis in HepG2 cells and HUVECs via inhibition of HIF-1α protein expression and the secretion of VEGF protein by blocking PI3K/AKT/mTOR/P70S6K and RAS/MEK/ERK/MNK mediated signal transduction pathways [247].