Apart from the main anticancer mechanisms, 1 has been reported to inhibit HIF-1 binding activity to DNA in hepatocellular carcinoma Hep3B cells [60,61], but the effects in vascular smooth muscular cells demonstrated that actinomycin D (1) solely attenuated angiotensin II-mediated induction of HIF-1α protein expression levels and not the hypoxia-dependent induction [62]. Here, HIF1A is linked to hepatocellular carcinoma.