The benzochromenones 45–52 (Figure 5) significantly inhibited HIF-1 activation in T47D breast tumor cells with IC50 values ranging from 1.7 to 7.3 μM and from 0.6 to 3.0 μM for hypoxia-induced and 1,10-phenanthroline-induced activation, respectively [240]. This evidence concerns the gene HIF1A and breast neoplasm.