Sodwanone V (82) (Figure 8) is featured as the most active, inhibiting both hypoxia- and phenanthroline-induced HIF-1 activation in T47D breast tumor cells and being the only sodwanone derivative suppressing hypoxia-induced HIF-1 activation in PC-3 prostate tumor cells [314]. The gene discussed is HIF1A; the disease is prostate neoplasm.