HLA-B*18:01, HLA-B*35:03, HLA-38:01, HLA-B*44:02, and HLA-B*51:01 were associated with protection against COVID-19 among the Brazilian population [49,77]; whereas HLA-B*44, HLA-B*44:02, and HLA-B*58:01 were associated with greater risk in population reports for SARS-CoV-2 susceptibility, COVID-19 severity, and death. This evidence concerns the gene HLA-B and COVID-19.