There a few studies describing an upregulation of EGFR leading to remodelling of the desmosome by tyrosine phosphorylation of the plakoglobin, changing the interaction with desmoplakin in the desmosome, and you can speculate if this has implications in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC) [29]. The gene discussed is DSP; the disease is Arrhythmogenic right ventricular dysplasia.