In this study, the authors investigated PLWH who had CD4 levels < 200 cells/mL or previous AIDS using multiple variant-specific live-virus NTs and demonstrated that vaccination with an Omicron-adapted vaccine induced a similar increase of nAbs against the WT and BA.5 in previously SARS-CoV-2-infected and non-infected PLWH [21]. The gene discussed is CD4; the disease is AIDS.