In addition, there is emerging evidence regarding the utility of tests to identify CDKN2A deletions in the differential diagnosis of Spitz nevus versus spitzoid melanoma [53]; therefore, this line of research, as well as the applicability of the p16-CD8-Ki67 triple immunohistochemical score, may be successfully explored in the future. The gene discussed is CDKN2A; the disease is spitzoid melanoma.