Although the association between the absence of p16 and increased values of Ki67 is proven to be involved in increasing the aggressiveness of melanoma, these indicators also denote an individual role in truncal cutaneous ulcerated melanomas with increased Breslow index and present vascular invasion (in the case of lack of expression of p16) and reduced survival (in the case of Ki67) [36]. The gene discussed is CDKN2A; the disease is melanoma.