In addition, in the review conducted by Levanat et al., it was discovered that a heterozygous CDKN2A gene defect could be detected in a relative of a melanoma patient not yet diagnosed with this condition, which would indicate a clear predisposition to develop melanocytic cutaneous malignancies, but without the obligation for melanoma to occur, however, during their lifetime [51]. Here, CDKN2A is linked to melanoma.