BRAF and neoplasm: According to the ESMO guidelines, “If the tumour is BRAF wild-type (WT) at the V600 locus (class I BRAF mutant), sequencing the loci of the other known minor BRAF mutations (class II and class III BRAF mutant) to confirm WT status and testing for NRAS and c-kit mutations are recommended [II, C] [...].